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Thematic Alpha

Providing programmatic exposure to sector outperformance through investment in thematic, innovative healthcare platforms and companies.


The Fund will target, and aim to benefit from, long-term ‘megatrends’ (Demographics, Urbanization, Digitalization and Environment) prioritising large and medium-sized companies in developed markets. The investment manager defines ‘megatrends’ as factors that transform civilization and sub-themes may include Robotics, Security, Cloud Technology, Virtual Life, Digital Data, Life Sciences, Health Care, Entertainment, Education, Water, Agriculture, Waste, Clean Energy, Mobility, Infrastructure and Financial Edge. The investment manager exploits original proprietary multi-factor scoring system based on 10 factors and no less than 100 sub-factors as a quantitative tool for determining securities with advantageous characteristics.


Market and portfolio insights, webinars and podcasts from across our Thematic Alpha Fund to provide our investors with the guidance they demand to navigate the changing world we are living in.

Insights - 2023 

2023 Macro Outlook & Investment Themes

Group Overview - 2023

Discipline. Focus. Clarity. These are what set us apart. Rather than chase every fad, we hone in on...


Market and portfolio insights, webinars and podcasts from across our investment teams.

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Meet the team

Natalia Kovalevskaya
Natalia Kovalevskaya Portfolio Manager

Natalia joined Signet in 2020 as Investment Director taking part in managing and developing growing portfolio of healthcare investments in both private and public companies. She has extensive experience in deal sourcing, due diligence, valuation, and execution of life sciences investment opportunities as well as in managing and developing portfolios of biotechnology companies at various stages of development.

Prior to Signet, from 2017 Natalia focused on early-stage private life sciences companies in Europe working within entrepreneurial biotech ecosystem in Europe with academic start-ups and technology transfer offices and contributing to early-stage investment rounds. She also founded and actively fund raised for a seed fund dedicated to building early-stage life sciences ventures.

Prior to healthcare investing, Natalia was a Director at UBS Investment Bank from 2015 where she led structured financing transactions for institutional investors. Her expertise spans various financial products and asset classes with focus on global emerging markets. Her clients include extensive network of European institutional investors such as pension funds, hedge funds and real money asset managers. Natalia started her career in investment banking at Citi in London in 2009 on analyst graduate program and worked in Capital Markets Origination and Global Markets divisions moving on to VTB Capital in 2012.

Natalia holds a BSc in Biochemistry from Imperial College London, MSc Management with a focus on pharmaceutical industry from London School of Economics, and an MEng in Food Technology Engineering from Moscow State University of Applied Biotechnology.

Natalia is fluent in English, Russian, Italian, French and speaks conversational German.

Serge Umansky
Serge Umansky Senior Portfolio Manager

Serge Umansky is a Managing Director of Signet FFF Capital AG. He is a specialist in absolute return strategies with 12 years of experience in numerical analysis in engineering and over 25 years of investment and risk management. From 1977, he headed the research laboratory at the Ukranian Academy of Sciences in Kiev, focusing on numerical analysis and developing numerical models and software for aerospace applications. In 1989, he was hired by the Germany-based EWCO GmbH where he led implementation and support of financial management systems for corporate clients in Central Europe. In 1991, he joined WIR Corporation in the United States where he designed and developed computerised trading models and software tools for quantitative trading strategies. From 1993, he was appointed CIO of New Capital Markets in Washington, DC where he developed investment strategies, managed multi asset funds and designed proprietary portfolio management software. He then moved into a consultancy role with ICG consulting, L.L.C. for international debt restructuring advisory, private equity investments and research. In 1999, he joined Signet Research and Advisory as CIO where he was responsible for portfolio construction and investments selection, risk management, as well as quantitative and qualitative portfolio analysis. From 2016, he co-founded a number of Signet subsidiary advisory companies, Whiteridge Advisor SA in 2016 and Metadvice Limited in 2018. In January 2020, he was appointed CEO of Signet Capital Management Limited and acts as a head of Healthcare Investments team at Signet Global.